Phototoxicity evaluation
Light is good for health, and many drugs themselves will not cause harm to the human body, but some drugs can produce phototoxicity under the action of light, and it is necessary to consider the evaluation of phototoxicity at this time. According to the requirements of ICH S10 and NMPA, we have established in vivo and in vitro phototoxicity evaluation methods, and have more than 10 years of experience in skin phototoxicity evaluation.
Category: Non-clinical safety evaluation
Medicines for human purposes
Light is good for health, and many drugs themselves will not cause harm to the human body, but some drugs can produce phototoxicity under the action of light, and it is necessary to consider the evaluation of phototoxicity at this time. According to the requirements of ICH S10 and NMPA, we have established in vivo and in vitro phototoxicity evaluation methods, and have more than 10 years of experience in skin phototoxicity evaluation.
Phototoxicity test
Phototoxicity test in vitro:
3T3 cell neutral red light toxicity test
In vivo phototoxicity test (guinea pig, rat, mouse) :
Neutral red light toxicity test of 3T3 cells in vitro
Skin phototoxicity test of in vivo and dermal administration in guinea pigs
Skin phototoxicity test of drug administration in vivo and skin administration in rats
Skin phototoxicity test of drug administration in vivo and skin administration in mice
Skin phototoxicity test of drug administration in vivo and skin administration in BN rats
Skin photoallergic reaction test in guinea pigs
